Visceral mast cell-like tumours ( feline gastrointestinal eosinophilic sclerosing fibroplasia ) occur in the pyloric sphincter, ileocecocolic junction or colon and small intestine. Twenty five percent of these cases also have lymph node involvement  . The lesions are typically characterized by eosinophilic inflammation, large reactive fibroblasts, and trabeculae of dense collagen similar to mast cell tumours. However, intralesional bacteria are commonly identified in about half of cases ( Clostridium perfringens and E. coli ) and all of the ileocecocolic junction and colon lesions  .
Gueck T, Aschenbach JR, Fuhrmann H.
Institute of Physiological Chemistry, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 1, 04103 Leipzig, Germany. [email protected]
We investigated the influence of vitamin E on mediator activity and release in a canine mastocytoma cell line (C2) as a model for canine atopic dermatitis. Cells were incubated without and with vitamin E (100 microm) for 24 h. The histamine and prostaglandin D2 (PGD2) release as well as the chymase and tryptase activity were measured. To stimulate the PGD2 and histamine release, cells were incubated with the wasp venom peptide mastoparan (50 microm) for 30 or 45 min. Nonstimulated as well as mastoparan-stimulated histamine and PGD2 release was reduced significantly in vitamin E-treated cells. The activity of chymase tended to decrease, but the tryptase activity of C2 cells was not influenced by vitamin E. These results indicate that vitamin E decreased the production and release of inflammatory mediators in C2 cells, suggesting that vitamin E might have a possible beneficial effect in inflammatory diseases.