As a non-aromatizing androgen, dihydrotestosterone is extremely potent. Aromatization refers to the conversion of testosterone or anabolic steroids into estrogen. High estrogenic activity causes bloating, acne, water retention and oily skin. As dihydrotestosterone does not aromatize even at high dosages, users do not face the aforementioned side-effects. Lack of water retention also has a hardening effect on muscle tissue, in bodybuilders. Being a powerful androgen, dihydrotestosterone is also responsible for a shift in the estrogen-testosterone ratio in the body. Due to its predominant androgenic component, the steroid has a stimulating effect on the adreno-pituitary functions, and causes neurological excitation in the ‘sexual orientation areas of the brain’. This in turn, spikes sex drive in males.
One study appeared to show that gw 50156 side effects included the growth of cancer cells but on further inspection, the results could be considered misleading. The study of gw1516 which was carried out on mice included 1000 times the recommended dose, taken over a prolonged period of time. As no individual would be taking such an inflated level of gw501516, there is debatable value attached to this particular study. Nevertheless, despite the criticism of this study, it was sufficient for GSK to drop the project so shouldn’t be dismissed completely.
For women, things are a bit different. They do not need SERMs because they produce so little testosterone naturally that suppression isn’t as detrimental. However, Anavar and Winstrol act much like testosterone in the female body, and using the combination over the course of four to six weeks can create a hormonal imbalance. Women who simply come off steroids cold turkey, even after a few weeks, may notice undesirable effects like fatigue and irritability. To avoid this, simply reducing dose toward the end of the cycle can help tremendously.